As the Colombia Cup season progresses, the match between Independiente Medellin vs Independiente Santa Fe on 25 September 2025 is set to deliver excitement. Predictions for Today suggests that Independiente Medellin or Draw will likely emerge victorious, with a predicted probability of 71%. Check out our additional predictions for Over/Under 2.5 Goals, Both Teams to Score, Half-Time, Correct Score, Corners, and Cards.